Eight-note fold regulator
Gene expression in cells is dynamically and intricately regulated in response to both external and internal signals. Transcription factors (TFs) bind to promoter regions to either activate or repress the expression of target genes. Therefore, research on TFs is crucial for understanding how cells adapt at the transcriptional level when they detect changes in molecular signals. The Cha group has been delving into how the DNA-binding activities of TFs are modulated at the atomic level.
EnfR: hydrogen production controlling transcription factor in archaea
Da-Woon Bae¶, Seong Hyuk Lee¶, Ji Hye Park, Se-Young Son, Yuxi Lin, Jung Hyen Lee, Bo-Ram Jang, Kyu-Ho Lee, Young-Ho Lee, Hyun Sook Lee, Sung Gyun Kang, Byoung Sik Kim, Sun-Shin Cha*
"An archaeal transcription factor EnfR with a novel ‘eighth note’ fold controls hydrogen production of a hyperthermophilic archaeon Thermococcus onnurineus NA1 "Nucleic Acids Research, Aug 31;gkad699. doi: 10.1093/nar/gkad699. (2023)
The Fur superfamily: metal sensing transcription factors in bacteria
Young Jun An¶, Bo-Eun Ahn¶, A-Reum Han, Hae-Mi Kim, Kyung Min Chung, Jung-Ho Shin, Yoo-Bok Cho,
Jung-Hye Roe* and Sun-Shin Cha*
"Structural basis for the specialization of Nur, a nickel-specific Fur homologue, in metal sensing and DNA recognition"
Nucleic Acids Research, Jun;37(10):3442-3451 (2009)
Jung-Ho Shin¶, Hoi Jong Jung¶, Young Jun An, Yoo-Bok Cho, Sun-Shin Cha*, Jung-Hye Roe*
"Graded expression of zinc-responsive genes through two regulatory zinc-binding sites in Zur"
PNAS, Mar 22;108(12):5045-5050 (2011)
Seung-Hwan Choi, Kang-Lok Lee, Jung-Ho Shin, Yoo-Bok Cho, Sun-Shin Cha, and Jung-Hye Roe*
"Zinc-dependent regulation of zinc import and export genes by Zur"
Nature Communications, 8:15812 (2017)